2021 Nissan Murano vs 2022 Toyota Sequoia
Overview | |
MSRP$32,810 | MSRP$50,500 |
Listings83 | Listings37 |
Ratings & Reviews | |
User Reviews | User Reviews |
Expert reviews7.8 out of 10 | Expert reviews7.3 out of 10 |
Pros
Cons
| Pros
Cons
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2021 Nissan Murano Reviews SummaryWhile most midsize SUVs offer three rows, the 2021 Nissan Murano focuses on two rows of comfortable seating. Rivals like the Honda Passport have come on the scene in recent years, but Nissan’s comfortable crossover never left. The Murano was introduced in 2002 as a 2003 model, and the third generation arrived for the 2015 model year. Last refreshed for 2019, the Murano carries over into the 2021 model year largely unchanged, although it does get some additional standard safety features. | |
2022 Toyota Sequoia Reviews SummaryThe 2022 Toyota Sequoia shares its platform with the Toyota Tundra pickup truck. It comes with rear-wheel-drive (RWD) or available four-wheel-drive (4WD) drivetrains, except TRD Pro models, which come with standard 4WD. The Sequoia and comes in six trim levels: SR5, TRD Sport, TRD Pro, Limited, Platinum, and the Nightshade Special Edition. While competitors have refreshed their full-size SUVs over the past few years, Toyota has stood pat with the Sequoia, relying on minor cosmetic updates to keep the SUV in the hunt since 2008. | |
No video found | No video found |
Popular Features & Specs | |
Engine3.5L 260 hp V6 | Engine5.7L 381 hp V8 |
Drive TrainFWD | Drive Train4X2 |
Seating Capacity5 | Seating Capacity8 |
Horsepower260 hp @ 6000 rpm | Horsepower381 hp @ 5600 rpm |
MPG City20 | MPG City13 |
MPG Highway28 | MPG Highway17 |
Engine | |
Engine Name3.5L 260 hp V6 | Engine Name5.7L 381 hp V8 |
Torque240 lb-ft @ 4400 rpm | Torque401 lb-ft @ 3600 rpm |
Horsepower260 hp @ 6000 rpm | Horsepower381 hp @ 5600 rpm |
DrivetrainFWD | Drivetrain4X2 |
Fuel Economy | |
MPG City20 | MPG City13 |
MPG Highway28 | MPG Highway17 |
Interior | |
Seating Capacity5 | Seating Capacity8 |
Key Features | |
Sunroof/Moonroof | Sunroof/MoonroofStandard |
Safety | |
Front Crash Overall5 | Front Crash Overall |
Side Crash Overall5 | Side Crash Overall |
Dimensions & Capacity | |
Cargo Space32.1 cu ft | Cargo Space18.9 cu ft |
Curb Weight3833 lbs | Curb Weight5730 lbs |
Height67.8 in | Height77.0 in |
Length192.8 in | Length205.1 in |
Width75.4 in | Width79.9 in |
Wheelbase111.2 in | Wheelbase122.0 in |
Maximum Payload1277 lbs | Maximum Payload1405 lbs |
Number of doors4 | Number of doors4 |
Maximum Towing Capacity | Maximum Towing Capacity7400 lbs |
Standard Towing Capacity | Standard Towing Capacity7400 lbs |
Overview | ||
MSRP | $32,810 | $50,500 |
Listings | ||
Ratings & Reviews | ||
User reviews | ||
Expert reviews | 7.8 out of 10Read full review | 7.3 out of 10Read full review |
Pros & cons | Pros
Cons
| Pros
Cons
|
Summary | While most midsize SUVs offer three rows, the 2021 Nissan Murano focuses on two rows of comfortable seating. Rivals like the Honda Passport have come on the scene in recent years, but Nissan’s comfortable crossover never left. The Murano was introduced in 2002 as a 2003 model, and the third generation arrived for the 2015 model year. Last refreshed for 2019, the Murano carries over into the 2021 model year largely unchanged, although it does get some additional standard safety features. | The 2022 Toyota Sequoia shares its platform with the Toyota Tundra pickup truck. It comes with rear-wheel-drive (RWD) or available four-wheel-drive (4WD) drivetrains, except TRD Pro models, which come with standard 4WD. The Sequoia and comes in six trim levels: SR5, TRD Sport, TRD Pro, Limited, Platinum, and the Nightshade Special Edition. While competitors have refreshed their full-size SUVs over the past few years, Toyota has stood pat with the Sequoia, relying on minor cosmetic updates to keep the SUV in the hunt since 2008. |
Video | No video found | No video found |
Popular Features & Specs | ||
Engine | 3.5L 260 hp V6 | 5.7L 381 hp V8 |
Drive Train | FWD | 4X2 |
Seating Capacity | 5 | 8 |
Horsepower | 260 hp @ 6000 rpm | 381 hp @ 5600 rpm |
MPG City | 20 | 13 |
MPG Highway | 28 | 17 |
Engine | ||
Engine Name | 3.5L 260 hp V6 | 5.7L 381 hp V8 |
Torque | 240 lb-ft @ 4400 rpm | 401 lb-ft @ 3600 rpm |
Horsepower | 260 hp @ 6000 rpm | 381 hp @ 5600 rpm |
Drivetrain | FWD | 4X2 |
Fuel Economy | ||
MPG City | 20 | 13 |
MPG Highway | 28 | 17 |
Interior | ||
Seating Capacity | 5 | 8 |
Key Features | ||
Sunroof/Moonroof | Standard | |
Safety | ||
Front Crash Overall | 5 | |
Side Crash Overall | 5 | |
Dimensions & Capacity | ||
Cargo Space | 32.1 cu ft | 18.9 cu ft |
Curb Weight | 3833 lbs | 5730 lbs |
Height | 67.8 in | 77.0 in |
Length | 192.8 in | 205.1 in |
Width | 75.4 in | 79.9 in |
Wheelbase | 111.2 in | 122.0 in |
Maximum Payload | 1277 lbs | 1405 lbs |
Number of doors | 4 | 4 |
Maximum Towing Capacity | 7400 lbs | |
Standard Towing Capacity | 7400 lbs | |
The 2021 Nissan Murano had a design that once seemed ahead of its time, but by 2021, its L-shaped LED headlights and contoured front end had become standard in car design. Its interior was more conservative, focusing on comfort for commutes and road trips. The cabin's restrained styling ensured that controls were intuitively placed, minimizing any learning curve for drivers. The Murano offered four trims: S, SV, SL, and Platinum, each adding more features, from basic amenities like dual-zone climate control and an 8-inch touchscreen to luxury touches like a panoramic moonroof and premium leather in the Platinum trim.
In contrast, the 2022 Toyota Sequoia continued its second generation into its 14th year, maintaining a mature design. Its exterior was marked by a modest grille and elegant wheel arches, with a large presence at 77 inches tall and 205.1 inches long. Inside, the Sequoia's design felt dated compared to modern trends, with a 7-inch touchscreen and a 4.5-inch driver information screen. However, the interior was built to last, with high-quality materials and a focus on durability. The Nightshade Special Edition added modern touches with darkened chrome and black-painted finishes, updating its look.














The 2021 Nissan Murano was powered by a single engine option: a 3.5-liter V6 producing 260 horsepower and 240 pound-feet of torque. This engine, paired with a continuously variable transmission (CVT), offered standard front-wheel drive and optional all-wheel drive. The V6 provided strong low-speed acceleration, making it ideal for city driving, though the CVT dulled its power at higher speeds. The Murano prioritized comfort, offering a smooth ride that absorbed road bumps well, making it a great choice for commuting and road trips. However, its towing capacity was limited to 1,500 pounds, lower than many midsize and even some compact SUVs.
The 2022 Toyota Sequoia featured a 5.7-liter i-Force V8 engine, delivering 381 horsepower and 401 pound-feet of torque. This engine was paired with a six-speed automatic transmission, offering a lockable Torsen limited-slip center differential and a two-speed transfer case in 4WD models. The Sequoia's truck roots gave it a payload capacity of around 1,300 pounds and a towing capacity of 7,400 pounds. Despite its weight, the Sequoia offered a smooth and stable ride, with excellent off-road capabilities thanks to its body-on-frame construction and independent double-wishbone suspension. However, its fuel economy was a drawback, with ratings of 13 mpg city and 17 mpg highway.
The 2021 Nissan Murano offered up to 67 cubic feet of cargo space with the rear seats folded, and 32.1 cubic feet with them in use. While this was less than some competitors, the Murano excelled in ease-of-use, with a traditional shifter design and a center console full of trays and cubbies. Its focus on two rows of seating provided ample headroom and legroom, with partially reclining second-row seats for added comfort.
The 2022 Toyota Sequoia prioritized passenger comfort across its three rows, with features like three-zone climate control and a power moonroof. The center console and glove compartment offered ample storage, and rear passengers had access to cup holders and power outlets. The Sequoia's cargo space was impressive, with 18.9 cubic feet behind the third row, expanding to 66.6 cubic feet with the third row folded, and a massive 120.1 cubic feet with both the second and third rows down.
The 2021 Nissan Murano came standard with an 8-inch touchscreen infotainment system, featuring a user-friendly menu layout and physical buttons for easy navigation. It included Apple CarPlay and Android Auto, with available upgrades like an 11-speaker Bose stereo system and navigation.
The 2022 Toyota Sequoia's technology felt outdated, with a 7-inch touchscreen and a clunky operating system. While Apple CarPlay and Android Auto were standard, the 4.5-inch driver information screen was outclassed by modern digital dashboards. The Sequoia offered WiFi connectivity and SiriusXM satellite radio, with available upgrades like a 12-speaker audio system and a premium audio package with 14 JBL speakers.
The 2021 Nissan Murano featured Nissan Safety Shield 360, with standard driver assistance features like reverse automatic emergency braking, blind-spot monitoring, and lane departure warning. Additional features like adaptive cruise control and a surround-view parking monitor were available as upgrades.
The 2022 Toyota Sequoia lacked crash-test ratings from NHTSA and IIHS but offered a comprehensive suite of safety features. Toyota Safety Sense P included pre-collision systems, adaptive cruise control, and lane-departure alert. The STAR safety system added stability control, traction control, and anti-lock brakes, among other features. The Sequoia also included a full complement of airbags and child safety features.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Nissan Murano is 7.8 out of 10, while the 2022 Toyota Sequoia scores 7.3 out of 10. Based on these ratings, the 2021 Nissan Murano is the recommended choice, offering a more modern design, better technology, and a higher overall rating.
Choose the 2021 Nissan Murano if:
- You prioritize a comfortable and intuitive interior design for commuting and road trips.
- You value modern technology features like an 8-inch touchscreen with Apple CarPlay and Android Auto.
- You prefer a vehicle with a focus on two-row seating comfort and ease-of-use.
Choose the 2022 Toyota Sequoia if:
- You need a large SUV with ample passenger space and impressive cargo capacity.
- You require a vehicle with strong towing capabilities and off-road potential.
- You appreciate a durable and reliable vehicle with a focus on safety features.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Nissan Murano is 7.8 out of 10, while the 2022 Toyota Sequoia scores 7.3 out of 10. Based on these ratings, the 2021 Nissan Murano is the recommended choice, offering a more modern design, better technology, and a higher overall rating.
Choose the 2021 Nissan Murano if:
Shop Now- You prioritize a comfortable and intuitive interior design for commuting and road trips.
- You value modern technology features like an 8-inch touchscreen with Apple CarPlay and Android Auto.
- You prefer a vehicle with a focus on two-row seating comfort and ease-of-use.
Choose the 2022 Toyota Sequoia if:
Shop Now- You need a large SUV with ample passenger space and impressive cargo capacity.
- You require a vehicle with strong towing capabilities and off-road potential.
- You appreciate a durable and reliable vehicle with a focus on safety features.

By: CarGurus + AI
At CarGurus, our team of experienced automotive writers remain at the heart of our content operation, conducting hands-on car tests and writing insightful guides that are backed by years of industry experience. To complement this, we are harnessing AI to make our content offering more diverse and more helpful to shoppers than ever. To achieve this, our AI systems are based exclusively on CarGurus content, ratings and data, so that what we produce is both unique to CarGurus, and uniquely helpful to car shoppers.







































